The 101 on e Cigarettes Infographic American Heart Association E Cigarettes, Vapes, and other Electronic Nicotine Delivery Systems (ENDS) FDA New research from the University of New South Wales warns that vaping is not the safe alternative it was once thought to be. The review of studies from 2017 to 2025 links About E Cigarettes (Vapes) Smoking and Tobacco Use CDC Nonnicotine vapes may be marketed as safe, but many still contain chemicals, have unknown health effects, and aren't FDAregulated. Teens are using them more ofteneven alongside nicotine vapes. No ecigarette is riskfree.